Abstract
We evaluated the in vivo efficacy of three beta-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described beta-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Anthrax / drug therapy*
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Anthrax / mortality
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Anthrax / prevention & control*
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Antigens, Bacterial / metabolism
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Bacillus anthracis / drug effects
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Bacillus anthracis / pathogenicity*
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Bacterial Toxins / antagonists & inhibitors*
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Bacterial Toxins / metabolism
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Disease Models, Animal
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Mice
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Treatment Outcome
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beta-Cyclodextrins / chemistry*
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beta-Cyclodextrins / pharmacology*
Substances
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Antigens, Bacterial
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Bacterial Toxins
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anthrax toxin
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beta-Cyclodextrins